Her many roles include Traviata, Lucia, Armida (Rinaldo), Alcina, Merry Widow, Rosalinde, Susanna, Countess Almaviva, Donna Anna, Marguerite (Faust), Manon, Marie (Wozzeck), Jenny (Mahagonny), Aida, Carmen, Contesse de la Roche (Soldaten); just to mention a few.

Noëmi Nadelmann has sung major roles at opera houses such as the Metropolitan Opera in New York, Opéra National Paris, Vienna State Opera, Deutsche Oper Berlin, Komische Oper Berlin, State Opera Berlin, State Opera House Hamburg, Dutch National Opera Amsterdam, Lyric Opera of Chicago, Operhaus Zürich, New National Theatre Tokio, Bolshoi Theatre in Moscow, Bavarian State Opera in Munich, Dresden Semper Opera and many more.

Conductors Noëmi Nadelmann had the honour to work with include Nicolaus Harnoncourt, Christian Thielemann, Simone Young, Franz Welser-Möst, Teodor Currentzis, Vladimir Jurowski, Christoph Eschenbach, Kurt Masur, Asher Fish. There are several CDs and DVDs available on the market. In the french Chopin Film la note bleue she embodied the role of the opera singer Pauline Viardot-Garcia with french actress Sophie Marceau.

Noëmi Nadelmann was awarded the esteemed Wolfgang Amadeus Mozart Prize by the Goethe-Stiftung for her outstanding artistic achievements.